SOLUBLE TRANSFERRIN RECEPTORS
STFR


Back

CLINICAL SIGNIFICANCE
The extracellular transport of iron is accomplished by binding to transferrin and by a surface receptor that mediates the flow of iron transfer into the cells. The soluble transferrin receptor (sTfR) is the fraction of the receptor that is cleaved from the cell membrane, and shed into the bloodstream as truncated forms of transferrin receptor monomers, complexed with apotransferrin. As 85-90% of the sTfR molecules are found in hemopoietic cells the concentration of sTfR in serum reflects the hemopoietic activity and it can be a marker of functional iron. sTfR levels are not influenced from acute phase conditions so they can be used for the differential diagnosis of anemia due to chronic diseases (ACD) from iron deficiency anemia (IDA). Increased sTfR is observed at hemolytic anemia, sickle cell anemia, B12 deficiency and at pregnancy when there is functional iron deficiency.
CHARACTERISTICS

Form: Liquid ready-to-use
Shelf life: 12 months @ 2-8 C
On-Board Stability: 30 days
Sample: Fresh serum
Detection limit: 1.5 nmol/L
Linearity: 1.9-280 nmol/L


Packaging
For Use On
MEDILYZER
EX-OLYMPUS
GENERAL PURPOSE
SIEMENS ADVIA
Packaging
Please Request Info
4x100 Tests
Please Request Info
2x200 Tests