IMMUNOGLOBULIN E
IgE


Back

CLINICAL SIGNIFICANCE
IgE is mostly produced in the lymph glands and the mucous membranes of the respiratory and gastrointestinal system. IgE is related to type I allergic reactions (medium oversensitivity) that are observed immediately after contact with the antigen. Antigens such as pollen, food, parasites and insect secretions cause the production of specific IgE molecules by B-cells, with the assistance of adjuvant T cells. IgE is afterwards bound to stem cells, sensitizing them. The next time the antigen is recognized by the sensitized stem cells, the bound IgE antibodies are linked, bringing forth the release of substances that cause rhinitis, anaphylaxis, asthma and eczema.

Increased IgE levels are observed in cases of allergic, atopic diseases, asthma, allergic catarrh, hyperimmunoglobulinemia E and Wiskott-Aldrich, and IgE myeloma. Low IgE values appear in advanced neoplasms, ataxia telangiectasia, agammaglobulinemia, and cases of hypersensitivity. It is possible that some geographically restricted populations exhibit even complete hereditary lack of IgE.
CHARACTERISTICS

Form: Liquid ready-to-use
Shelf life: 18 months @ 2-8 C
On-Board Stability: 60 days
Sample: Serum or plasma with heparin, EDTA, or citrate
Detection limit: 5.7 IU/mL
Linearity: 5.7-1500 IU/mL


Packaging
For Use On
MEDILYZER
EX-OLYMPUS
GENERAL PURPOSE
SIEMENS ADVIA
Packaging
Please Request Info
4x50 Tests
Please Request Info
4x100 Tests