HAPTOGLOBIN

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CLINICAL SIGNIFICANCE
Haptoglobin is an a2-glycoprotein that binds hemoglobin permanently. Each haptoglobin monomer can bind up to 2 hemoglobin ab-dimers, the equivalent to one molecule of hemoglobin. These complexes are removed from the circulation by Kupffer’s cells of the liver where proteins are deconstructed and aminoacids and iron are reused. Therefore, haptoglobin is essential for retaining iron and averts possible damage to renal tubes, preventing the excretion of hemoglobin.

Hatoglobin analyses are primarily used for testing or monitoring the course of hemolytic disorders. Plasma levels are increased if there are acute inflammatory processes, tissue necrosis or malignancy, protein loss syndroms (ie. renal syndrome or enteropathy with protein loss) and in treatment with corticosteroids. Plasma levels are decreased in hemolytic diseases and non-active erythropoiesis, genetic deficiency, with either endogenous or exogenous estrogens, and in hepatocellular diseases.
CHARACTERISTICS

Form: Liquid ready-to-use
Shelf life: 12 months @ 2-8 C
On-Board Stability: 60 days
Sample: Serum or plasma with EDTA
Detection limit: 0.8 mg/dL
Linearity: 3.9-300 mg/dL


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