C-REACTIVE PROTEIN
CRP


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CLINICAL SIGNIFICANCE
Increased CRP concentrations in the serum are observed in cases of inflammation, tissue necrosis or wounds. In contrast to other acute phase proteins, like a1-antitrypsine and haptoglobuline, CRP is not significantly affected by non-steroid hormones of endogenous (pregnancy) or exogenous origin. It appears, however, that pharmaceutical treatment with steroid or non anti-inflammatory medicines may significantly reduce CRP levels. CRP levels in serum are increased more dramatically when compared to other acute phase proteins. Thus, CRP comprises one of the most useful proteins of that category for the clinical assessment of patients. Increase of CRP levels during an inflammation is observed even in the neonatal period, when it’s very significant for the diagnosis of bacterial septicemia. CRP levels may also rise in viral infections or spirochaete. Therefore, in lack of wound, very high CRP levels may indicate bacterial or viral infection. In bacterial meningitis very high initial CRP levels may be prognostic of neurological complications. Consecutive measurements of CRP levels are exceptionally useful for patient monitoring during the anti-microbial treatment, as well as post-operatively when protein levels increase in bacterial infection. Measuring CRP levels is also useful during clinical assessment in rheumatoid arthritis, systemic lupus erythematosus, vascular syndrome, bowel inflammation and myocardial infarction.

No cases of CRP deficiency have been reported. Levels are lower for infants than adults. Direct immunoturbidimetry and nephelometry are not sensitive enough for the diagnosis of premature infants or infinitesimal increases in acute phase proteins of the newborn.
CHARACTERISTICS

Form: Liquid ready-to-use
Shelf life: 24 months @ 2-8 C
On-Board Stability: 60 days
Sample: Fresh,non hemolysed, non lipemic serum or heparinized plasma
Detection limit: 0.13 mg/dL
Linearity: up to 30 mg/dL


Packaging
For Use On
MEDILYZER
EX-OLYMPUS
GENERAL PURPOSE
SIEMENS ADVIA
Packaging
6x50 Tests & 6x180 Tests
4x50 Tests & 4x200 Tests
R1 3x100, R2 75
4x100 Tests & 4x300 Tests