a1 ANTITRYPSIN

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CLINICAL SIGNIFICANCE
α1-antitrypsin(α1-AT), a 51kDa glycoprotein is present in plasma and interstitial fluid. α1-AT is an acute phase reactant, which inhibits most proteolytic enzymes that have a serine amino acid at their active site like trypsin, chymotrypsin, as well as pancreatic and especially leukocyte elastase, which is released in the process of phagocytosis from polymorphonuclear leukocytes. Increased levels of α1-AT are common in inflammation (infections, rheumatic diseases), tissue necrosis, malignancy, and trauma. Elevated levels of α1-AT are also seen in late pregnancy and during estrogen therapy. Low levels of the protein are found in neonatal respiratory distress syndrome, severe neonatal hepatitis, preterminal disease of the pancreas and in severe protein depleting enteropathies.
CHARACTERISTICS

Form: Liquid ready-to-use
Shelf life: 12 months @ 2-8 C
On-Board Stability: 60 days
Sample: Serum or plasma with EDTA
Detection limit: 2.3 mg/dL
Linearity: 2.4-475 mg/dL


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