a1 ACID GLYCOPROTEIN

Back

CLINICAL SIGNIFICANCE
A1 acid glycoprotein or orosomucoid (ORM) is a highly acidic protein, soluble in water. As an acute phase reactant its synthesis is controlled by a combination of the major regulatory mediators, i.e. glucocorticoids and a cytokine network involving mainly interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF alpha), interleukin-6 and IL-6 related cytokines. The physiological role of AGP remains uncertain although in vitro it has been shown to modify platelet adhesiveness and to suppress immunoreactivity. In addition it binds many basic drugs and some hormones including progesterone. AGP is an acute phase reactant whose plasma levels show a 3-4-fold increase in most conditions associated with inflammation and tissue necrosis. The protein levels are also increased by glucocorticoid effects either endogenous or exogenous. Decreased levels or AGP are observed in infancy and early childhood, at the end stage of hepatocellular disease, in nephrotic syndrome and protein depleting enteropathies.
CHARACTERISTICS

Form: Liquid ready-to-use
Shelf life: 12 months @ 2-8 C
On-Board Stability: 60 days
Sample: Serum
Detection limit: 1.0 mg/dL
Linearity: 1-185 mg/dL


Packaging
For Use On
MEDILYZER
EX-OLYMPUS
GENERAL PURPOSE
SIEMENS ADVIA
Packaging
Please Request Info
4x50 Tests
Please Request Info
4x80 Tests