URINARY PROTEIN
CSF


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CLINICAL SIGNIFICANCE
Measurement of total protein in urine is important in the diagnosis and treatment of diseases associated with renal, cardiac and thyroid function. These diseases cause proteinurea which is attributed to: (a) increased glomerular permeability (glomerular proteinuria), (b) defective tubular reabsorption (tubular proteinuria), (c) increased concentration of low molecular weight protein (overload proteinuria), (d) abnormal secretion of the protein into the urinary tract (postrenal proteinuria).

Healthy people may exceed normal protein excretion levels after strenuous exercise or with dehydration. Some foods may affect protein levels. Drugs that can cause increased excretion level include: acetaminophen, antibiotics, gentamycin and non-steroidal anti-inflammatory drugs (when associated with analgesic nephropathy).

Measurement of total protein in CSF is indicative of increased permeability of blood-CSF barrier to plasma proteins or increased local synthesis of immunoglobulins. The increased permeability of the blood-CSF barrier may be attributed to brain tumor, endocerebral hemorrhage, bacterial or viral meningitis or poliomyelitis. Increased immunoglobulin synthesis may occur due to demyelinating diseases such as multiple sclerosis.
CHARACTERISTICS

Form: Liquid, ready-to-use
Shelf life: 24 months @ 2-8 C
On-Board Stability: 60 days
Sample: Urine or CSF
Detection limit: 0.17 mg/dL
Linearity: 1.83–250 mg/L


Packaging
For Use On
MEDILYZER
EX-OLYMPUS
GENERAL PURPOSE
SIEMENS ADVIA
Packaging
6x50 Tests
4x100 Tests
R1 4x125 mL
4x100 Tests