UREA

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CLINICAL SIGNIFICANCE
Urea is synthesized in the liver as the final product of protein and amino acid metabolism. Urea synthesis is therefore dependent on daily protein intake and endogenous protein metabolism. Most of the urea produced during these metabolic processes is eliminated by glomerular filtration. During diuresis a large quantity of urea is excreted in the urine and plasma urea concentration is low. During antidiuresis which may occur in oliguric heart failure, exsiccosis or thirst, urea rediffuses in the tubules at an increased rate and plasma urea is increased. Prerenal elevation of urea occurs in cardiac decompensation, increased protein catabolism, and water depletion. Urea levels may be elevated due to renal causes such as acute glomerulonephritis, chronic nephritis, polycystic kidney, tubular necrosis, and nephrosclerosis. Post renal elevation of urea may be caused by obstruction of the urinary tract. In dialysis patients the urea concentration is representative of protein degradation and is also an indicator of metabolic status.
CHARACTERISTICS

Form: Liquid, ready-to-use
Shelf life: 18 months @ 2-8 C
On-Board Stability: 40 days
Sample: Non hemolysed serum or heparinised plasma (morning sample)
Detection limit: 0.7 mg/dL
Linearity: 0.7–500 mg/dL


Packaging
For Use On
MEDILYZER
EX-OLYMPUS
GENERAL PURPOSE
SIEMENS ADVIA
Packaging
6x220 Tests
4x500 Tests
R1 2x125 mL, R2 2x125 mL
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