UNSATURATED IRON BINDING CAPACITY
UIBC


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CLINICAL SIGNIFICANCE
The determined concentration of iron in serum is usually Fe(III) bound to serum transferrin and does not include the iron contained in serum as free hemoglobin. As only about one third of transferrin iron binding sites are taken up by Fe(III), normally, serum transferrin has a high iron binding capacity. That is named unsaturated, or dormant, iron binding capacity. UIBC measurement can be used in combination with the concentration of serum iron for the determination of total iron binding capacity (TIBC), that is, the maximum concentration of iron that serum proteins—mainly transferrin—can bind.

TIBC is reduced in chronic infections, malignancy, iron poisoning, kidney disease, Kwashiorok type pellagra, and thalassemia. Common causes of TIBC increase include iron deficiency anemia, advanced pregnancy, oral contraception and infectious hepatitis.
CHARACTERISTICS

Form: Liquid, ready-to-use
Shelf life: 18 months @ 2-8 C
On-Board Stability: 30 days
Sample: Non hemolysed serum or heparinised plasma
Detection limit: 21 μg/dL
Linearity: 21–400 μg/dL


Packaging
For Use On
MEDILYZER
EX-OLYMPUS
GENERAL PURPOSE
SIEMENS ADVIA
Packaging
6x100 Tests
4x100 Tests
R1 108 mL, R2 20 mL, R3 6 mL
4x200 Tests