LACTATE DEHYDROGENASE
LDH P-L


Back

CLINICAL SIGNIFICANCE
L-Lactate dehydrogenase is a NAD+ oxidoreductase, catalysing the reverse oxidation of L-lactate to pyruvate using NAD+ as a hydrogen receptor. Total LDH activity in serum is expressed by 5 isoenzymes (LDH-1 to LDH-5) which are differentiated on their subunits composition. An LDH-1 level higher than the LDH-2 level (a "flipped pattern"), suggests myocardial infarction (damage to heart tissues releases into the bloodstream heart LDH, which is rich in LDH-1).

LDH is often used as a marker of tissue breakdown. Generally, increased levels of LDH can be attributed to any cell damage that results in cytoplasm release (embolism, leukemias, hemolytic anemias, hepatitis (non viral), sickle cell anemia, lymphoma, myocardial infarction or pulmonary embolism).

As LDH is abundant in red blood cells it can also function as a marker for hemolysis. A blood sample that has been handled incorrectly can show false-positively high levels of LDH due to erythrocyte damage.

LDH is used to follow-up cancer (especially lymphoma) patients, as cancer cells have a high rate of turnover, with destroyed cells leading to an elevated LDH activity.

The enzyme is also found in cerebrospinal fluid where high levels of lactate dehydrogenase are often associated with bacterial or viral meningitis.

Elevated LDH may also be seen in Aran-Duchenne and Kugelberg-Welander spinal muscular atrophy, dermatomyositis, polymyositis, and as a result of strenuous physical exercise, megaloblastic anemias, renal infarction, chronic glomerular disease, myoskeletal diseases.
CHARACTERISTICS

Form: Liquid, ready-to-use
Shelf life: 24 months @ 2-8 C
On-Board Stability: 30 days
Sample: Non hemolyzed serum or plasma with heparin
Detection limit: 3 U/L
Linearity: 17-2000 U/L


Packaging
For Use On
MEDILYZER
EX-OLYMPUS
GENERAL PURPOSE
SIEMENS ADVIA
Packaging
6x50 Tests & 6x200 Tests
4x100 Tests & 4x500 Tests
R1 3x120 mL, R2 90 mL
Please Request Info