LACTATE

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CLINICAL SIGNIFICANCE
L-Lactate is produced from pyruvate by the enzymatic action of lactate dehydrogenase (LDH). Lactate is constantly produced during normal metabolism and exercise but doesn’t increase in concentration until the rate of lactate production exceeds the rate of lactate removal. There are two major clinical settings in which lactate acidosis occurs (1) conditions associated with hypoxia e.g. shock, congestive heart failure, myocardial infarction, blood loss and primary edema, and (2) metabolic or drug/toxin related disorders. Examples of metabolic disorders include diabetes mellitus, hepatic disease, and neoplasia. Congenital metabolic disorders include type I glycogen storage disease. Examples of drug/toxins which give rise to elevated lactate are methanol, ethanol, acetaminophen, epinephrine. Recent report indicates that the measurement of CSF lactate may be a useful screening test for CNS disease and in aid in distinguishing bacterial from viral meningitis. Moreover increased lactate levels at CSF are observed at reduced cerebral blood flow of oxygenation, increased intracranial pressure, seizures, intracranial hemorrhage, brain abscess, multiple sclerosis, primary or metastatic CNS carcinoma etc.
CHARACTERISTICS

Form: Liquid, ready-to-use
Shelf life: 12 months @ 2-8 C
On-Board Stability: 60 days
Sample: Oxalate-, fluoride-plasma
Detection limit: 0 mg/L
Linearity: 0–1200 mg/L


Packaging
For Use On
MEDILYZER
EX-OLYMPUS
GENERAL PURPOSE
SIEMENS ADVIA
Packaging
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4x50 Tests
R1 2x60 mL, R2 2x60mL
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