ALKALINE PHOSPHATASE
ALP


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CLINICAL SIGNIFICANCE
The origins of the major phosphatases are liver, bone, intestine, endometrium and lung. Ingestion of a meal increases the intestinal isoenzyme of ALP in serum. ALP activity increases in children during periods of rapid growth, in females in the last trimester of pregnancy, and after menopause. Increased levels of ALP are related to bone metabolism (ALP is increased in childhood or during the healing of a fracture), primary and secondary hyperparathyroidism, osteomalacia, and juvenile rickets. Moreover increased levels are observed at various bone diseases like metastatic carcinoma in bone, osteogenic sarcoma, myeloma, Hodgkin’s disease if bones are invaded, Gaucher’s disease with bone resorption, Paget’s disease and Cushing’s syndrome. Elevated levels of ALP are noted in liver diseases like infectious mononucleosis, uncomplicated extrahepatic biliary obstruction, cytomegalovirus infection in infants, cholangeitis and cholangiolitis, hepatocellular jaundice, portal cirrhosis, primary hepatocellular carcinoma, secondary carcinoma, extrahepatic sepsis. ALP deficiency is observed in hypothyroidism, gross anemia, achondroplasia, hypophosphatasemia, deposition of radioactive elements on the bones, severe vitamin B12 deficiency, Kwashiorkor syndrome, and nutritial deficiency in zinc or magnesium.
CHARACTERISTICS

Form: Liquid ready-to-use
Shelf life: 18 months @ 2-8 C
On-Board Stability: 14 days
Sample: Non hemolyzed serum or heparinized plasma
Detection limit: 1.0 U/L
Linearity: 5-1500 U/L


Packaging
For Use On
MEDILYZER
EX-OLYMPUS
GENERAL PURPOSE
SIEMENS ADVIA
Packaging
6x50 Tests & 6x200 Tests
4x100 Tests & 4x500 Tests
R1 2x100 mL, R2 2x100 mL
4x150 Tests & 4x700 Tests