ALDOLASE

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CLINICAL SIGNIFICANCE
Aldolase is an enzyme that catalyses the aldol reaction: the substrate, fructose 1,6-bisphosphate (F-1,6-BP) is broken down by aldolase into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP). This reaction is a part of glycolysis. Increased levels of the enzyme are observed during acute hepatitis (viral or toxic) and other liver diseases, muscular dystrophy, myocardial infarction, gangrene, carcinomas (lung, breast, genitourinary system), melanoma, CNS tumors, granulocytic leukemia, megaloblastic anemia, delirium tremens, 60 – 80% of patients with acute psychosis and schizophrenia, tetanus, hematopoietic malignancies, hemolytic anemias, tissue infarction, and acute pancreatitis. The enzyme is detected at reduced levels at hereditary fructose intolerance.
CHARACTERISTICS

Form: Freeze-dried
Shelf life: 12 months @ 2-8 C
On-Board Stability: 7 days
Sample: Serum
Detection limit: 0.17 U/L
Linearity: 0.37-75.0 U/L


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