ADENOSINE DEAMINASE
ADA ADA2


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CLINICAL SIGNIFICANCE
Adenosine Deaminase (ADA) is an enzyme that catalyzes the conversion of adenosine into inosine. The concentration of enzyme in serum is increased in several conditions, and the measurement of enzyme levels can be used as a diagnostic tool in several cases.

ADA activity is increased in cases of hepatitis, cirrhosis, hemolytic anemia, rheumatoid and typhoid fever, Mediterranean anemia, myelogenous leukemia, tuberculosis, and autoimmune diseases. Especially in children, enzyme activity is significantly increased in cases of tuberculosis, when compared to any other respiratory system disease. When combined with γ-GT, it can contribute greatly to the diagnosis of hepatic conditions. It should be noted that enzyme levels are significantly low in conditions of the biliary tract, while it is systematically increased in chronic liver conditions.

ΑDA enzymatic activity is due to two isoenzymes, ADA1 and ADA2. The ΑDA1 isoenzyme is found as monomer and dimer in all cell types, exhibiting the greatest activity in lymph cells and monocytes. The ADA2, on the contrary, only appears in monocytes. In tuberculous pleural effusions, ADA is mainly increased because of the ADA2 isoenzyme, suggesting increased production of the monocyte enzyme. In effusions caused by other reasons, increased ADA activity comes from lymphocytes, or neutrophils, and mainly because of the ADA1 isoenzyme.
CHARACTERISTICS

Form: Liquid ready-to-use
Shelf life: 12 months @ 2-8 C
On-Board Stability: 30 days
Sample: Serum, pleural effusion fluid.
Detection limit: 2.4 U/L
Linearity: 120 U/L


Packaging
For Use On
MEDILYZER
EX-OLYMPUS
GENERAL PURPOSE
SIEMENS ADVIA
Packaging
2x50 Tests
2x50 + 2x50 Tests
Please Request Info
2x90 + 2x90 Tests